Nachshen D A, Drapeau P
Biophys J. 1982 May;38(2):205-8. doi: 10.1016/S0006-3495(82)84548-7.
A simple model is proposed, whereby a single buffering system for intracellular calcium accounts for the steep external Ca dependence of neurotransmitter release during depolarization of the presynaptic nerve terminal. Ca entry and buffering in the nerve terminal are assumed to be saturable; release is assumed to be proportional to intracellular Ca. The novel feature of this model is that it explains the apparent cooperative relationship between transmitter release and extracellular calcium, without invoking cooperative Ca binding.
提出了一个简单的模型，即用于细胞内钙的单一缓冲系统解释了突触前神经末梢去极化期间神经递质释放对细胞外钙的强烈依赖性。假定神经末梢中的钙内流和缓冲是可饱和的；假定释放与细胞内钙成正比。该模型的新颖之处在于，它解释了递质释放与细胞外钙之间明显的协同关系，而无需调用协同钙结合。
