Kelly D G, Miller L J, Malagelada J R, Huizenga K A, Markowitz H
Gastroenterology. 1982 Sep;83(3):581-9.
Seven patients with giant hypertrophic gastropathy participated in a gastric intubation perfusion study to investigate the route and mechanism of protein leakage associated with this disease. All patients had gastric tight junctions wider than those in healthy controls. Acute administration of propantheline bromide reduced gastric albumin leakage (-50.7%, p less than 0.05) and concurrently decreased width of tight junctions (p less than 0.05) in all patients. Another antisecretory agent, cimetidine, had no consistent effect on protein leakage or on the width of tight junctions. Pentagastrin and bethanechol chloride increased protein loss but had no effect on the width of tight junctions. These results are consistent with the hypothesis that proteins may take a paracellular route via the tight junctions as they traverse the gastric mucosa and that this may have a cholinergic mechanism.
七名巨大肥厚性胃炎患者参与了一项胃插管灌注研究，以探究与该疾病相关的蛋白质渗漏途径及机制。所有患者的胃紧密连接均比健康对照者的更宽。急性给予溴丙胺太林可减少胃白蛋白渗漏（-50.7%，p<0.05），并同时减小所有患者紧密连接的宽度（p<0.05）。另一种抗分泌药物西咪替丁对蛋白质渗漏或紧密连接宽度没有一致的影响。五肽胃泌素和氯贝胆碱增加了蛋白质丢失，但对紧密连接宽度没有影响。这些结果与以下假设一致，即蛋白质在穿过胃黏膜时可能通过紧密连接走细胞旁途径，且这可能具有胆碱能机制。
