Takaya J, Kawamura Y, Kino M, Kawashima Y, Yamamoto A, Kobayashi Y
Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, Moriguchi, Osaka 570, Japan.
Pediatr Radiol. 1997 Feb;27(2):178-80. doi: 10.1007/s002470050095.
We report the case of a 3-year-old boy with Ménétrier's disease who presented with prominent anasarca associated with hypoproteinemia, but no proteinuria. An early sonogram of the stomach demonstrated thickening of the gastric wall which was found to resolve gradually on serial sonograms. Consequently, we considered that the submucosal layer of the gastric wall was particularly thickened as a result of Ménétrier's disease. A gastric biopsy was performed 18 days after onset of the disease, and an electron-microscopic examination of the sample disclosed persistent widening of gastric tight junctions by more than 10 nm. The patient made a full recovery on supportive treatment in 3 weeks. Ultrasonography provided us with a potent tool not only in making the diagnosis, but also in following the course of the disease.
我们报告了一例3岁患有梅内特里尔病的男孩，该患儿出现与低蛋白血症相关的显著全身性水肿，但无蛋白尿。早期胃部超声检查显示胃壁增厚，后续系列超声检查发现胃壁增厚逐渐消退。因此，我们认为胃壁黏膜下层增厚是梅内特里尔病所致。在疾病发作18天后进行了胃活检，对样本的电子显微镜检查发现胃紧密连接持续增宽超过10纳米。患者在支持治疗3周后完全康复。超声检查不仅为我们提供了诊断工具，还能用于追踪疾病进程。
