Mehendale H M
Environ Health Perspect. 1977 Dec;21:275-8. doi: 10.1289/ehp.7721275.
Hexachlorocyclopentadiene is eliminated from the body efficiently by urinary excretion. Although direct evidence is not available, it appears that expiration may be another important route of elimination. Of the administered dose 9% is excreted in the bile in 1 hr, approximately equal to the amount of fecal excretion in 7 days, suggesting enterohepatic circulation. After a single dose, HCPD decays from the blood biexponentially with a terminal phase half-life of 60 min. Of the tissues analyzed kidney, followed by liver, concentrate HCPD 1 hr or 7 days after exposure to any significant extent. Subcellularly, HCPD is predominantly associated with cytosol fractions of both kidney as well as liver, observations consistent with rapid elimination of HCPD after a single exposure. Preexposure to HCPD (50 mg/kg-day for 3 days) resulted in unaltered blood decay curves and biliary excretion, but increased the concentration in the kidneys after a single subsequent challenge.
六氯环戊二烯可通过尿液排泄有效地从体内消除。虽然尚无直接证据，但呼气似乎可能是另一条重要的消除途径。给药剂量的9%在1小时内随胆汁排出，这大约相当于7天内粪便中的排泄量，提示存在肠肝循环。单次给药后，六氯环戊二烯从血液中呈双指数衰减，终末相半衰期为60分钟。在分析的组织中，肾脏其次是肝脏，在接触后1小时或7天会大量蓄积六氯环戊二烯。在亚细胞水平上，六氯环戊二烯主要与肾脏和肝脏的胞质溶胶部分相关，这些观察结果与单次接触后六氯环戊二烯的快速消除一致。预先接触六氯环戊二烯（50毫克/千克·天，持续3天）不会改变血液衰减曲线和胆汁排泄，但在随后单次接触后会增加肾脏中的浓度。
