Dorough H W, Ranieri T A
Drug Chem Toxicol. 1984;7(1):73-89. doi: 10.3109/01480548409014174.
14C-Hexachlorocyclopentadiene (HEX, C56 ) was administered to adult rats and mice as a single oral dose (2.5 and 25 mg/kg) and as a component of the diet (1, 5 and 25 ppm) for a maximum of 30 days. The primary route of excretion was via the feces (-70% of dose) with low elimination in the urine (approximately 15%). Biliary excretion of only 16% with 66% still voided in the feces of bile duct cannulated rats suggested that the majority of orally consumed HEX was not absorbed. However, extensive degradation apparently occurred in the gut since little of the fecal material was of an apolar nature. The kidney, liver, ovaries and fat were the major sites of deposition of 14C-HEX equivalents. In rats, the kidney contained the highest levels of residues, whereas in mice the residues in the liver exceeded those in the kidney. Other than this difference, the fate of HEX in rats and mice, both male and female, was quite similar and in each case the tissue residues reached a plateau after about two weeks on the HEX-containing diets.
将14C-六氯环戊二烯（HEX，C56）以单次口服剂量（2.5和25毫克/千克）和作为饮食成分（1、5和25 ppm）给予成年大鼠和小鼠，最长持续30天。排泄的主要途径是通过粪便（约占剂量的70%），尿液中的排泄量较低（约15%）。胆管插管大鼠的胆汁排泄仅为16%，66%仍随粪便排出，这表明口服摄入的大部分HEX未被吸收。然而，由于粪便物质几乎没有非极性性质，肠道内显然发生了广泛的降解。肾脏、肝脏、卵巢和脂肪是14C-HEX等效物的主要沉积部位。在大鼠中，肾脏中的残留水平最高，而在小鼠中，肝脏中的残留量超过了肾脏。除了这种差异外，HEX在雄性和雌性大鼠和小鼠中的命运相当相似，在每种情况下，在含HEX饮食喂养约两周后，组织残留量达到稳定水平。
