控制尿量和电解质排泄的中枢胆碱能机制。
Central cholinergic mechanism for control of urine volume and electrolyte excretion.
作者信息
Misra V, Bapat S K, Bharadwaj U R, Saxena V C, Singh K N
出版信息
Indian J Physiol Pharmacol. 1977 Jul-Sep;21(3):203-6.
PMID:612604
Abstract
- Studies were conducted on urine volume and electrolyte excretion chiefly of Na and K in anaesthetized hydrated dogs. 2. Central injection of acetylcholine caused a dose dependent antidiuretic response but without any change in excretion of urinary Sodium (UNa) and Potassium (UK). 3. After central atropinization, antidiuretic response to acetylcholine was partially blocked without any effect on electrolyte excretion. 4. Intracerebroventricularly (I.C.V.) administered acetylcholine after vagotomy and spinalectomy, each done separately and together also elicited an antidiuretic response. There was no effect on electrolyte excretion. 5. It is thus suggested that acetylcholine may be acting on central cholinergic receptors concerned with A.D.H. release.
摘要
- 对麻醉状态下补充水分的犬的尿量以及主要是钠和钾的电解质排泄情况进行了研究。2. 向中枢注射乙酰胆碱会引起剂量依赖性抗利尿反应，但尿钠（UNa）和尿钾（UK）排泄无任何变化。3. 中枢给予阿托品后，对乙酰胆碱的抗利尿反应被部分阻断，而对电解质排泄无影响。4. 在分别及联合进行迷走神经切断术和脊髓切断术后，脑室内（I.C.V.）给予乙酰胆碱也会引发抗利尿反应。对电解质排泄无影响。5. 因此表明，乙酰胆碱可能作用于与抗利尿激素释放有关的中枢胆碱能受体。
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