Jolliffe I G, Newton J M
J Pharm Pharmacol. 1982 Jul;34(7):415-9. doi: 10.1111/j.2042-7158.1982.tb04747.x.
An instrumented mG2 capsule filling machine simulator has been employed to study the effects of the amount of compression (compression ratio) on the capsule fill weight uniformity and measured compression and ejection stresses. Four size fractions of lactose were studied (mean particle sizes 15.6, 17.8, 37.5 and 155.2 micron). The range of compression over which satisfactory filling could be achieved was large for fine, cohesive powders but decreased with increasing particle size. The lower limit of filling ability was the ability to retain the powder and the amount of compression needed to achieve retention increased with increasing particle size. The upper limit on compression, was the compaction of the powder which prevented the piston acting to cause retention. Large particle sizes were able to undergo only a small change in volume before compaction occurred whilst fine, cohesive powders were considerably more compressible and hence could be filled satisfactorily at higher compression settings.
一台配备仪器的mG2胶囊填充机模拟器已被用于研究压缩量（压缩比）对胶囊填充重量均匀性以及所测量的压缩应力和弹出应力的影响。研究了四种乳糖粒度级分（平均粒径分别为15.6、17.8、37.5和155.2微米）。对于细的、有粘性的粉末，能够实现满意填充的压缩范围较大，但随着粒径增大而减小。填充能力的下限是保留粉末的能力，实现保留所需的压缩量随粒径增大而增加。压缩的上限是粉末的压实，这会阻止活塞作用以实现保留。大粒径粉末在压实发生之前只能经历很小的体积变化，而细的、有粘性的粉末更具可压缩性，因此在更高的压缩设置下可以实现满意的填充。
