Jolliffe I G, Newton J M
J Pharm Pharmacol. 1983 Feb;35(2):74-8. doi: 10.1111/j.2042-7158.1983.tb04273.x.
A production mG2 G36 machine has been employed to study the effects of compression on the capsule filling properties of four particle size fractions of lactose having a range of flow properties. The effect of the surface texture of the dosator nozzle bore on capsule filling is also investigated. Fine, cohesive powders gave uniform fill weights over a whole range of compression settings but as increasingly free-flowing powders were used, this range diminishes. For both types of powder, the upper limit on compression is set by compaction of powder which produces poor fill weights; coarse, free-flowing powders, which are less compressible, compact at lower compressions. Free-flowing powders, in particular, also require a minimum compression to be retained. Resurfaced nozzles produced improved capsule filling. One nozzle surface produced slightly more uniform fill weights and was unaffected by powder coating of the nozzle suggesting that an optimum surface texture exists for capsule filling. The results are similar to those obtained using the mG2 simulator and hence validate the latter's use in studying production capsule filling.
一台生产型mG2 G36机器被用于研究压缩对具有一系列流动特性的四种乳糖粒度级分的胶囊填充特性的影响。还研究了定量给料器喷嘴孔的表面质地对胶囊填充的影响。细的、有粘性的粉末在整个压缩设置范围内给出均匀的填充重量，但随着使用越来越易流动的粉末，这个范围会减小。对于这两种类型的粉末，压缩的上限是由产生不良填充重量的粉末压实所设定的；粗的、易流动的粉末，其可压缩性较小，在较低压缩下压实。特别是易流动的粉末，也需要保持最小压缩。重新表面处理的喷嘴改善了胶囊填充。一种喷嘴表面产生的填充重量略更均匀，并且不受喷嘴粉末涂层的影响，这表明存在用于胶囊填充的最佳表面质地。结果与使用mG2模拟器获得的结果相似，因此验证了后者在研究生产胶囊填充中的用途。
