Jolliffe I G, Newton J M
J Pharm Pharmacol. 1983 Jan;35(1):7-11. doi: 10.1111/j.2042-7158.1983.tb04253.x.
The effect on capsule filling, using an mG2 simulator, of the surface texture of the bore of the dosator nozzle has been investigated for size fractions of lactose. Since the angle of powder-wall friction between the powder and the nozzle cannot be readily measured insitu, this was determined using flat plates with similar surface textures fitted into a Jenike shear cell apparatus. The problems of reproducing surface textures on both types of surface are discussed and a lapping process employed as the most suitable method. Angles of wall friction for the nozzle surfaces were extrapolated from the values obtained from flat plates of similar roughness. Capsule filling experiments, using the mG2 simulator, showed the three resurfaced nozzles produced more uniform fill weights with smaller measured compression and ejection stresses than an untreated nozzle surface. One lapped nozzle surface produced a slightly greater improvement than the others. This supports the concept of an optimum angle of wall friction for powder retention (and hence uniformity of fill) with a minimum of applied compression stress.
使用mG2模拟器，研究了剂量仪喷嘴孔的表面纹理对乳糖不同粒度级分胶囊填充的影响。由于粉末与喷嘴之间的粉壁摩擦角无法在原位轻松测量，因此使用具有相似表面纹理的平板安装在詹尼克剪切细胞仪中来确定该角度。讨论了在两种类型表面上重现表面纹理的问题，并采用研磨工艺作为最合适的方法。喷嘴表面的壁摩擦角是从具有相似粗糙度的平板获得的值外推而来的。使用mG2模拟器进行的胶囊填充实验表明，与未处理的喷嘴表面相比，三个重新表面处理的喷嘴产生了更均匀的填充重量，测量的压缩和弹射应力更小。一个研磨过的喷嘴表面比其他表面产生了稍大的改善。这支持了存在一个最佳壁摩擦角的概念，该角度有利于粉末保留（从而实现填充均匀性），同时施加的压缩应力最小。
