Raab A, Kojer G
Pharmacol Biochem Behav. 1982 Jul;17(1):77-83. doi: 10.1016/0091-3057(82)90266-0.
Experiments were carried out with female tree-shrews (Tupaia belangeri). Following 6-hydroxydopamine injections into the ventral tegmental area, considerable variations in tyrosine-hydroxylase activity in the respective target regions of the A10 area occurred. Depletion of the THY-activity in the septum (SE), the entorhinal cortex (ECO), the frontal cortex and the basal ganglia correlated with an impairment in the performance of a passive avoidance task (indicated by testing 24 hours postshock). Partial correlation analysis revealed that the variations of THY-activity in the SE and ECO are primarily related to this failure in passive avoidance acquisition.
实验使用雌性树鼩（笔尾树鼩）进行。向腹侧被盖区注射6-羟基多巴胺后，A10区各目标区域的酪氨酸羟化酶活性出现了相当大的变化。隔区（SE）、内嗅皮质（ECO）、额叶皮质和基底神经节中THY活性的降低与被动回避任务表现受损相关（通过电击后24小时测试表明）。偏相关分析显示，SE和ECO中THY活性的变化主要与被动回避习得失败有关。
