Ingemarsson I
Acta Obstet Gynecol Scand Suppl. 1982;108:29-34. doi: 10.3109/00016348209155340.
Modern beta-receptor agonists are potent inhibitors of uterine activity, both spontaneous and induced, and there are several indications for therapy, such as preterm labor, abnormal uterine activity during labor (with or without concomitant fetal distress), complicated cesarean sections, and others. In recent years the widespread use of beta-receptor agonists for preterm labor has been criticized and the efficacy of these drugs has been questioned, since the rate of preterm deliveries (before week 37) has remained unchanged. However, an analysis of preterm births in Sweden from 1973 to 1979 shows that the number of both preterm births before week 32 and of infants with birthweight below 1 500 g is declining, which is more interesting in terms of fetal outcome than is the crude preterm figure (before week 37). The introduction of routine use of beta-receptor agonists for preterm labor coincides with this decrease. It is concluded that these drugs can be of great value in many obstetrical situations.
现代β受体激动剂是子宫活动的强效抑制剂，无论是自发性还是诱发性子宫活动，且有多种治疗指征，如早产、分娩时异常子宫活动（伴或不伴有胎儿窘迫）、复杂剖宫产等。近年来，β受体激动剂在早产治疗中的广泛应用受到了批评，这些药物的疗效也受到质疑，因为早产（37周前）率一直没有变化。然而，对瑞典1973年至1979年早产情况的分析表明，32周前的早产数量以及出生体重低于1500克的婴儿数量都在下降，就胎儿结局而言，这比粗略的早产数字（37周前）更有意义。β受体激动剂用于早产的常规使用与这种下降同时出现。结论是，这些药物在许多产科情况下可能具有很大价值。
