Güttner J, Veckenstedt A, Heinecke H, Pusztai R
Acta Virol. 1982 May;26(3):148-55.
Quercetin protects mice from lethal Mengo M virus infection when given orally 12 and 1 hr before and 8, 24, 36, 48 and 56 hr after inoculation. No differences in the course of infection have been found between normal splenectomized or congenitally athymic mice. Likewise the effect of drug treatment was similar in all three models. Necrotic lesions in the main target organs (central nervous system, salivary and lacrimal glands, thymus, pancreas, kidneys and spleen) from both normal and immunodeficient animals were less severe and developed later in quercetin-treated mice than in placebo-treated ones. In a few quercetin-treated virus-infected survivors a slight and persistent encephalitis was seen. Quercetin enhanced the graft-versus-host reaction, but failed to affect the humoral antibody response of mice to sheep red blood cells. It is concluded that T- and B-lymphocytes seem involved neither in the pathogenesis of acute Mengo virus infection nor in the antiviral effect of quercetin.
槲皮素在接种前12小时和1小时以及接种后8、24、36、48和56小时口服时，可保护小鼠免受致死性门戈M病毒感染。在正常脾切除或先天性无胸腺小鼠之间未发现感染过程有差异。同样，药物治疗在所有三种模型中的效果相似。与安慰剂治疗的小鼠相比，槲皮素治疗的正常和免疫缺陷动物主要靶器官（中枢神经系统、唾液腺和泪腺、胸腺、胰腺、肾脏和脾脏）的坏死病变较轻且出现较晚。在少数经槲皮素治疗的病毒感染幸存者中，可见轻微且持续的脑炎。槲皮素增强了移植物抗宿主反应，但未能影响小鼠对绵羊红细胞的体液抗体反应。结论是，T淋巴细胞和B淋巴细胞似乎既不参与急性门戈病毒感染的发病机制，也不参与槲皮素的抗病毒作用。
