Flanagan R J, Storey G C, Holt D W, Farmer P B
J Pharm Pharmacol. 1982 Oct;34(10):638-43. doi: 10.1111/j.2042-7158.1982.tb04692.x.
Desethylamiodarone has been identified as the principal lipophilic metabolite of amiodarone present in plasma specimens from amiodarone-treated patients. This structure has been confirmed by probe-injection mass spectrometry of column effluent fractions and comparison with the authentic compound using both chromatographic and mass spectrometric techniques. Although there is no information available as to the pharmacological activity of desethylamiodarone in man, the plasma concentrations of this metabolite attained during chronic amiodarone therapy are similar to those of the parent compound (0.1-4 mg litre-1).
去乙基胺碘酮已被确定为胺碘酮在接受胺碘酮治疗患者血浆样本中的主要亲脂性代谢物。通过对柱流出物馏分进行探针注射质谱分析，并使用色谱和质谱技术与纯品化合物进行比较，已证实了该结构。尽管尚无关于去乙基胺碘酮在人体药理活性的信息，但在慢性胺碘酮治疗期间该代谢物达到的血浆浓度与母体化合物相似（0.1 - 4毫克/升）。
