胺碘酮及其去乙基代谢产物的肾脏排泄。
Renal elimination of amiodarone and its desethyl metabolite.
作者信息
Harris L, Hind C R, McKenna W J, Savage C, Krikler S J, Storey G C, Holt D W
出版信息
Postgrad Med J. 1983 Jul;59(693):440-2. doi: 10.1136/pgmj.59.693.440.
Abstract
Two patients in chronic renal failure receiving amiodarone for the treatment of refractory arrhythmias were commenced on dialysis, in one case, intermittent peritoneal dialysis, in the other, haemodialysis. Plasma concentrations of amiodarone and its desethyl metabolite were consistent with the dose received, whilst neither compound was recovered in the dialysate. In these patients and in 10 additional patients with normal renal function taking amiodarone, only negligible amounts of either compound were detected in urine. These findings suggest that amiodarone may be a suitable antiarrhythmic agent for use in patients with chronic renal failure.
摘要
两名慢性肾衰竭患者因顽固性心律失常接受胺碘酮治疗，其中一名开始进行间歇性腹膜透析，另一名开始进行血液透析。胺碘酮及其去乙基代谢物的血浆浓度与所接受的剂量一致，而在透析液中均未检测到这两种化合物。在这些患者以及另外10名肾功能正常且服用胺碘酮的患者中，尿液中仅检测到极少量的这两种化合物。这些发现表明，胺碘酮可能是适用于慢性肾衰竭患者的抗心律失常药物。
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