胺碘酮及其去乙基代谢产物的肾脏排泄。
Renal elimination of amiodarone and its desethyl metabolite.
作者信息
Harris L, Hind C R, McKenna W J, Savage C, Krikler S J, Storey G C, Holt D W
出版信息
Postgrad Med J. 1983 Jul;59(693):440-2. doi: 10.1136/pgmj.59.693.440.
Abstract
Two patients in chronic renal failure receiving amiodarone for the treatment of refractory arrhythmias were commenced on dialysis, in one case, intermittent peritoneal dialysis, in the other, haemodialysis. Plasma concentrations of amiodarone and its desethyl metabolite were consistent with the dose received, whilst neither compound was recovered in the dialysate. In these patients and in 10 additional patients with normal renal function taking amiodarone, only negligible amounts of either compound were detected in urine. These findings suggest that amiodarone may be a suitable antiarrhythmic agent for use in patients with chronic renal failure.
摘要
两名慢性肾衰竭患者因顽固性心律失常接受胺碘酮治疗，其中一名开始进行间歇性腹膜透析，另一名开始进行血液透析。胺碘酮及其去乙基代谢物的血浆浓度与所接受的剂量一致，而在透析液中均未检测到这两种化合物。在这些患者以及另外10名肾功能正常且服用胺碘酮的患者中，尿液中仅检测到极少量的这两种化合物。这些发现表明，胺碘酮可能是适用于慢性肾衰竭患者的抗心律失常药物。
相似文献
1
Renal elimination of amiodarone and its desethyl metabolite.胺碘酮及其去乙基代谢产物的肾脏排泄。
Postgrad Med J. 1983 Jul;59(693):440-2. doi: 10.1136/pgmj.59.693.440.
2
Pharmacokinetics of amiodarone, desethylamiodarone and other iodine-containing amiodarone metabolites.胺碘酮、去乙基胺碘酮及其他含碘胺碘酮代谢产物的药代动力学。
Eur J Clin Pharmacol. 1985;29(4):417-23. doi: 10.1007/BF00613455.
3
Use of amiodarone during pregnancy.妊娠期使用胺碘酮。
Postgrad Med J. 1985 Jan;61(711):75-7. doi: 10.1136/pgmj.61.711.75.
4
Amiodarone in patients on long-term dialysis.
N Engl J Med. 1983 Apr 14;308(15):906. doi: 10.1056/NEJM198304143081518.
5
Clinical pharmacokinetics of amiodarone.胺碘酮的临床药代动力学。
Clin Pharmacokinet. 1984 Mar-Apr;9(2):136-56. doi: 10.2165/00003088-198409020-00002.
6
Amiodarone pharmacokinetics.胺碘酮的药代动力学
Am Heart J. 1983 Oct;106(4 Pt 2):840-7. doi: 10.1016/0002-8703(83)90006-6.
7
Amiodarone and desethylamiodarone distribution in the atrium and adipose tissue of patients undergoing short- and long-term treatment with amiodarone.胺碘酮及去乙基胺碘酮在接受胺碘酮短期和长期治疗患者心房及脂肪组织中的分布情况。
J Am Coll Cardiol. 1986 Jul;8(1):210-3. doi: 10.1016/s0735-1097(86)80114-0.
8
The antiarrhythmic efficacy of amiodarone and desethylamiodarone, alone and in combination, in dogs with acute myocardial infarction.胺碘酮和去乙基胺碘酮单独及联合应用对急性心肌梗死犬的抗心律失常疗效。
Circulation. 1988 Jan;77(1):200-8. doi: 10.1161/01.cir.77.1.200.
9
[Interstitial pneumopathy and amiodarone].
Schweiz Med Wochenschr. 1986 Mar 22;116(12):377-82.
10
Clinical pharmacokinetics of the newer antiarrhythmic agents.新型抗心律失常药物的临床药代动力学
Clin Pharmacokinet. 1984 Sep-Oct;9(5):375-403. doi: 10.2165/00003088-198409050-00001.
引用本文的文献
1
Association of Rate-Control and Antiarrhythmic Medication Use and Risk of Ischemic Stroke and Death in Patients on Dialysis With Atrial Fibrillation.心房颤动透析患者心率控制与抗心律失常药物使用与缺血性卒中和死亡风险的关联
J Am Heart Assoc. 2025 Jun 17;14(12):e038511. doi: 10.1161/JAHA.124.038511. Epub 2025 Jun 16.
2
Amiodarone extraction by continuous renal replacement therapy: results from an ex vivo study.连续性肾脏替代治疗对胺碘酮的清除：一项体外研究的结果
J Artif Organs. 2025 Jun;28(2):275-279. doi: 10.1007/s10047-024-01475-7. Epub 2024 Oct 14.
3
Management of patients with heart failure and chronic kidney disease.心力衰竭和慢性肾脏病患者的管理。
Heart Fail Rev. 2024 Sep;29(5):989-1023. doi: 10.1007/s10741-024-10415-9. Epub 2024 Jul 29.
4
Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy.胺碘酮相关性视神经病变的临床与机制研究述评。
Biomolecules. 2022 Sep 14;12(9):1298. doi: 10.3390/biom12091298.
5
Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients with Atrial Tachyarrhythmias.胺碘酮对重症房性快速心律失常患者心率控制效果的建模
Clin Pharmacokinet. 2016 Aug;55(8):991-1002. doi: 10.1007/s40262-016-0372-9.
6
Drug therapy in haemodialysis patients. Special considerations in the elderly.血液透析患者的药物治疗。老年人的特殊注意事项。
Drugs Aging. 1998 Jun;12(6):441-59. doi: 10.2165/00002512-199812060-00003.
7
Class III antiarrhythmics in overdose. Presenting features and management principles.Ⅲ类抗心律失常药物过量。临床表现及处理原则。
Drug Saf. 1993 Dec;9(6):450-62. doi: 10.2165/00002018-199309060-00008.
8
Clinical pharmacokinetics of the newer antiarrhythmic agents.新型抗心律失常药物的临床药代动力学
Clin Pharmacokinet. 1984 Sep-Oct;9(5):375-403. doi: 10.2165/00003088-198409050-00001.
9
Amiodarone: the experience of the past decade.胺碘酮：过去十年的经验
Br Med J (Clin Res Ed). 1983 Dec 3;287(6406):1654-6. doi: 10.1136/bmj.287.6406.1654.
10
Clinical pharmacokinetics of amiodarone.胺碘酮的临床药代动力学。
Clin Pharmacokinet. 1984 Mar-Apr;9(2):136-56. doi: 10.2165/00003088-198409020-00002.
本文引用的文献
1
Possible association of pneumonitis with amiodarone therapy.
Am Heart J. 1980 Sep;100(3):412-3. doi: 10.1016/0002-8703(80)90165-9.
2
Rapid high-performance liquid chromatographic method for the measurement of amiodarone in blood plasma or serum at the concentrations attained during therapy.用于测定治疗期间血浆或血清中胺碘酮浓度的快速高效液相色谱法。
J Chromatogr. 1980 Jan 18;187(2):391-8. doi: 10.1016/s0021-9673(00)80471-9.
3
The effects of amiodarone on thyroid function.胺碘酮对甲状腺功能的影响。
Postgrad Med J. 1982 Nov;58(685):693-6. doi: 10.1136/pgmj.58.685.693.
4
High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in plasma or serum at the concentrations attained following a single 400-mg dose.
J Chromatogr. 1982 Aug 27;245(3):377-80. doi: 10.1016/s0021-9673(00)88028-0.
5
Clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.复发性室性心动过速或心室颤动长期治疗期间的临床疗效和电生理情况。
N Engl J Med. 1981 Sep 3;305(10):539-45. doi: 10.1056/NEJM198109033051002.
6
Dangers of amiodarone and anticoagulant treatment.胺碘酮与抗凝治疗的风险
Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):58. doi: 10.1136/bmj.283.6283.58-b.
7
Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients.
J Pharm Pharmacol. 1982 Oct;34(10):638-43. doi: 10.1111/j.2042-7158.1982.tb04692.x.
8
Iodide goiter and the pharmacologic effects of excess iodide.碘致甲状腺肿及过量碘的药理作用
Am J Med. 1969 Jul;47(1):101-24. doi: 10.1016/0002-9343(69)90245-9.
9
[Corneal thesaurismosis due to amiodarone. Current data].
Arch Ophtalmol Rev Gen Ophtalmol. 1971 Aug-Sep;31(8):581-96.
10
[Research on the benzofuran series. XXXVII. Comparative study of transit and metabolism of amiodarone in different species of animals and humans].
Arch Int Pharmacodyn Ther. 1969 Feb;177(2):340-59.
Zotero 插件