Jensen R K, Sleight S D, Goodman J I, Aust S D, Trosko J E
Carcinogenesis. 1982;3(10):1183-6. doi: 10.1093/carcin/3.10.1183.
Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system. Firemaster BP-6, a commercial mixture of PBB, and its major congener, 2,2',4,4',5,5'-hexabromobiphenyl (HBB) were used in this study. Tumor promoting ability was assessed by measuring enzyme altered foci exhibiting gamma glutamyl transpeptidase activity. Dietary concentrations of 10 and 100 p.p.m. of the mixture of PBB and of HBB were found to be promoters of hepatocarcinogenesis. The mixture of PBB had a greater tumor promoting ability than HBB.
对雌性斯普拉格-道利大鼠进行70%部分肝切除并给予二乙基亚硝胺（10毫克/千克体重）后，喂食多溴联苯（PBB）6个月，以确定PBB在两阶段肝癌发生试验系统中是否可作为肿瘤促进剂。本研究使用了PBB的商业混合物Firemaster BP-6及其主要同系物2,2',4,4',5,5'-六溴联苯（HBB）。通过测量表现出γ-谷氨酰转肽酶活性的酶改变灶来评估肿瘤促进能力。发现PBB混合物和HBB的膳食浓度为10和100 ppm时可促进肝癌发生。PBB混合物的肿瘤促进能力比HBB更强。
