de Leeuw P W, de Bos R, van Soest G A, Willemse P J, Birkenhäger W H
Clin Exp Hypertens A. 1982;4(11-12):2285-91. doi: 10.3109/10641968209062390.
In the present study we investigated the effect of three manoeuvres known to be associated with enhanced sympathetic activity on plasma levels of active and inactive renin. To this end, active and trypsin-activatable renin were measured in blood drawn from 12 untreated essential hypertensive patients before, during and after any of the following tests: isometric exercise (handgrip), noise stimulation and 45 degrees head-up tilt. These studies were repeated after the patients had been treated with either atenolol (n = 6) or SL 77499 (n = 6), an alpha-1 adrenoceptor blocking agent for 10 days. The results indicate that active and inactive renin often change in an unpredictable way in response to sympathetic stimulation. There are, as yet, no conclusive explanations which describe the behaviour of both forms of renin during these manoeuvres.
在本研究中，我们调查了已知与交感神经活动增强相关的三种操作对活性和非活性肾素血浆水平的影响。为此，在以下任何一项测试之前、期间和之后，从12名未经治疗的原发性高血压患者抽取的血液中测量活性肾素和胰蛋白酶可激活肾素：等长运动（握力）、噪声刺激和45度头高位倾斜。在患者接受阿替洛尔（n = 6）或α-1肾上腺素能受体阻断剂SL 77499（n = 6）治疗10天后，重复这些研究。结果表明，活性和非活性肾素对交感神经刺激的反应往往以不可预测的方式变化。迄今为止，尚无确凿的解释能够描述这两种形式的肾素在这些操作过程中的行为。
