Higaki J, Ogihara T, Nakamaru M, Shima K, Kumahara Y
Jpn Heart J. 1984 Jul;25(4):565-70. doi: 10.1536/ihj.25.565.
To examine the in vivo activation mechanism for the conversion of inactive to active renin in human plasma, we measured active, inactive and total plasma renin activity during an insulin tolerance test in normal subjects. Total renin was measured after trypsin activation of inactive renin. Inactive renin was calculated as the difference between total and active renin. With a decrease in the blood glucose level from 92 +/- 8 to 22 +/- 6 mg/dl (p less than 0.01), active renin increased significantly (p less than 0.01) from the basal level of 1.9 +/- 0.6 to 6.0 +/- 1.9 ng/ml.hr at 60 min after insulin injection. Total renin increased and inactive renin decreased slightly, but the changes were not statistically significant. The ratio of active to total renin showed a significant increase (p less than 0.01) at 60 min. These results suggest that stimulation of the endogenous sympathetic nervous system is involved in the in vivo activation of inactive renin.
为研究人血浆中无活性肾素转化为活性肾素的体内激活机制，我们在正常受试者的胰岛素耐量试验中测量了活性、无活性和总血浆肾素活性。在胰蛋白酶激活无活性肾素后测量总肾素。无活性肾素通过总肾素与活性肾素的差值计算得出。随着血糖水平从92±8降至22±6mg/dl（p<0.01），活性肾素在胰岛素注射后60分钟时从基础水平1.9±0.6显著增加（p<0.01）至6.0±1.9ng/ml·hr。总肾素增加，无活性肾素略有下降，但变化无统计学意义。活性肾素与总肾素的比值在60分钟时显著增加（p<0.01）。这些结果表明内源性交感神经系统的刺激参与了无活性肾素的体内激活。
