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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Schurr A, Rigor B M, Ho B T, Dafny N

Comp Biochem Physiol C Comp Pharmacol. 1982;73(2):323-30. doi: 10.1016/0306-4492(82)90129-0.

The present study compares the direct actions of morphine on two brain sites known to be rich in opiate receptors, namely, the caudate nucleus and the central gray. Recordings and morphine injections were made through a multibarrel glass micropipette using microiontophoresis. 2. Four different patterns of neuronal response to increasing currents of morphine were recorded in both brain regions. 3. Differences in the response to morphine between the two sites were detected in morphine-dependent rats. While the caudate neurons exhibited super-sensitivity to morphine, the neurons in the central gray displayed tolerance, and in some instances, dependence was evident when naloxone was administered. 4. The distribution of spontaneously active neurons within these two brain areas was found to be different in morphine-naive and morphine-dependent rats. 5. The electrophysiological findings of this study support the hypothesis of multiple opiate receptors.

本研究比较了吗啡对已知富含阿片受体的两个脑区，即尾状核和中央灰质的直接作用。记录和吗啡注射通过使用微离子透入法的多管玻璃微电极进行。2. 在两个脑区均记录到了对递增电流的吗啡有四种不同模式的神经元反应。3. 在吗啡依赖大鼠中检测到两个部位对吗啡反应的差异。尾状核神经元对吗啡表现出超敏感性，而中央灰质中的神经元则表现出耐受性，并且在某些情况下，给予纳洛酮时依赖性明显。4. 发现这两个脑区内自发活动神经元的分布在未接触过吗啡的大鼠和吗啡依赖大鼠中有所不同。5. 本研究的电生理结果支持多种阿片受体的假说。

Schurr A, Rigor B M, Ho B T, Dafny N

Comp Biochem Physiol C Comp Pharmacol. 1982;73(2):323-30. doi: 10.1016/0306-4492(82)90129-0.

The present study compares the direct actions of morphine on two brain sites known to be rich in opiate receptors, namely, the caudate nucleus and the central gray. Recordings and morphine injections were made through a multibarrel glass micropipette using microiontophoresis. 2. Four different patterns of neuronal response to increasing currents of morphine were recorded in both brain regions. 3. Differences in the response to morphine between the two sites were detected in morphine-dependent rats. While the caudate neurons exhibited super-sensitivity to morphine, the neurons in the central gray displayed tolerance, and in some instances, dependence was evident when naloxone was administered. 4. The distribution of spontaneously active neurons within these two brain areas was found to be different in morphine-naive and morphine-dependent rats. 5. The electrophysiological findings of this study support the hypothesis of multiple opiate receptors.

本研究比较了吗啡对已知富含阿片受体的两个脑区，即尾状核和中央灰质的直接作用。记录和吗啡注射通过使用微离子透入法的多管玻璃微电极进行。2. 在两个脑区均记录到了对递增电流的吗啡有四种不同模式的神经元反应。3. 在吗啡依赖大鼠中检测到两个部位对吗啡反应的差异。尾状核神经元对吗啡表现出超敏感性，而中央灰质中的神经元则表现出耐受性，并且在某些情况下，给予纳洛酮时依赖性明显。4. 发现这两个脑区内自发活动神经元的分布在未接触过吗啡的大鼠和吗啡依赖大鼠中有所不同。5. 本研究的电生理结果支持多种阿片受体的假说。