催产素诱导的大鼠子宫平滑肌无钙收缩：与乙二醇双乙醚二胺四乙酸（EGTA）及药物预孵育的影响
Oxytocin-induced Ca-free contraction of rat uterine smooth muscle: effects of preincubation with EGTA and drugs.
作者信息
Sakai K, Higuchi K, Yamaguchi T, Uchida M
出版信息
Gen Pharmacol. 1982;13(5):393-400. doi: 10.1016/0306-3623(82)90104-5.
PMID:6129175
Abstract
- The effect of the time of preincubation with 3 mM EGTA on oxytocin-induced Ca-free contraction of rat uterus was investigated. It was found 10(-2) unit/ml oxytocin induced sustained Ca-free contraction only after preincubation for 50 min or more. 2. The tension developed showed a biphasic relation to the time of preincubation with a minimum at 25 min. 3. Sustained Ca-free contraction could be repeated with only slight reduction in magnitude. 4. Oxytocin-induced Ca-free contraction was relaxed by isoproterenol. The effect of isoproterenol was inhibited by 3 X 10(-4) M 1,1-diphenyl-3-piperazino-1-butanol hydrochloride.
摘要
- 研究了3 mM乙二醇双乙醚二胺四乙酸（EGTA）预孵育时间对催产素诱导的大鼠子宫无钙收缩的影响。发现10(-2)单位/毫升催产素仅在预孵育50分钟或更长时间后才诱导出持续的无钙收缩。2. 所产生的张力与预孵育时间呈双相关系，在25分钟时达到最小值。3. 持续的无钙收缩可以重复，幅度仅有轻微降低。4. 异丙肾上腺素可使催产素诱导的无钙收缩松弛。3×10(-4) M 1,1-二苯基-3-哌嗪基-1-丁醇盐酸盐可抑制异丙肾上腺素的作用。
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