Puska P, Iacono J M, Nissinen A, Korhonen H J, Vartianinen E, Pietinen P, Dougherty R, Leino U, Mutanen M, Moisio S, Huttunen J
Lancet. 1983 Jan 1;1(8314-5):1-5. doi: 10.1016/s0140-6736(83)91556-8.
57 couples living in two communities of North Karelia, aged 30-50 years, were randomly allocated to three groups. After a 2-week baseline period group I followed a diet low in fat (23% of energy) with a high polyunsaturated/saturated (P/S) ratio (1 . 0), group II reduced daily salt intake from 192 mmol to 77 mmol, and group III (control group) continued the usual diet. After the 6-week intervention period groups I and II reverted to their usual diets. In group I systolic blood pressure declined from 138 . 4 to 129 . 5 mm Hg and diastolic blood pressure from 88 . 9 to 81 . 3 mm Hg during the intervention period; the values rose during switch-back. The fall was greater among hypertensive than among normotensive subjects. In groups II and III the mean blood pressure changed very little during the study.
居住在北卡累利阿两个社区的57对年龄在30至50岁之间的夫妇被随机分为三组。在为期2周的基线期后，第一组遵循低脂肪饮食（占能量的23%），多不饱和/饱和脂肪（P/S）比例较高（1.0），第二组将每日盐摄入量从192毫摩尔降至77毫摩尔，第三组（对照组）继续常规饮食。在为期6周的干预期后，第一组和第二组恢复到他们的常规饮食。在干预期，第一组收缩压从138.4毫米汞柱降至129.5毫米汞柱，舒张压从88.9毫米汞柱降至81.3毫米汞柱；在恢复常规饮食期间，这些值有所上升。高血压患者的下降幅度大于血压正常的受试者。在第二组和第三组中，研究期间平均血压变化很小。
