Houben H, Thien T, Wijnands G, Van't Laar A
Br J Clin Pharmacol. 1982 Dec;14(6):867-70. doi: 10.1111/j.1365-2125.1982.tb02051.x.
Haemodynamic effects of a cold pressor test (foot immersion for 6 min in water at 5 degrees C) without medication and after the non-selective beta-adrenoceptor blocker propranolol and the selective beta-adrenoceptor blocker metoprolol were studied in 17 volunteers. In the control study as well as in the study with the beta-adrenoceptor blockers cold exposure caused comparable changes, namely a blood pressure rise and a reduction of forearm blood flow. The increase in heart rate during cold exposure was clearly and equally reduced by both beta-adrenoceptor blockers. Plasma noradrenaline rose significantly by 47%, plasma adrenaline did not change. It is concluded, that as to this kind of stress, beta 1-selective-adrenoceptor blockade confers no important advantage over non-selective beta-adrenoceptor blockade.
在17名志愿者中研究了冷加压试验（将足部浸入5摄氏度的水中6分钟）在未用药时以及在使用非选择性β肾上腺素能受体阻滞剂普萘洛尔和选择性β肾上腺素能受体阻滞剂美托洛尔后的血流动力学效应。在对照研究以及使用β肾上腺素能受体阻滞剂的研究中，冷暴露引起了类似的变化，即血压升高和前臂血流量减少。两种β肾上腺素能受体阻滞剂均明显且同等程度地降低了冷暴露期间的心率升高。血浆去甲肾上腺素显著升高47%，血浆肾上腺素未发生变化。得出的结论是，对于这种应激，β1选择性肾上腺素能受体阻滞相对于非选择性β肾上腺素能受体阻滞没有重要优势。
