普萘洛尔对肼苯哒嗪治疗的高血压患者交感神经活动的影响。
Effect of propranolol on sympathetic nervous activity in hydrallazine-treated hypertensive patients.
作者信息
Velasco M, Romero E, Bertoncini H, Urbina-Quintana A, Guevara J, Hernández-Pieretti O
出版信息
Br J Clin Pharmacol. 1978 Sep;6(3):217-20. doi: 10.1111/j.1365-2125.1978.tb04587.x.
1 The effect of propranolol was examined on a) blood pressure and heart rate responses due to i.v. hydrallazine b) modification of these cardiovascular parameters during cold pressor test c) urinary catecholamine excretion rate. 2 Intravenous hydrallazine reduced significantly mean blood pressure by 15.2 mm Hg and increased heart rate by 24.9 beats/min. Propranolol reduced significantly mean blood pressure by 19.0 mm Hg and heart rate by 14.1 beats/min. Hydrallazine plus propranolol caused a significant reduction of mean blood pressure (by 37.7 mm Hg) but this was not accompanied by a significant fall in heart rate (by 3.3 beats/min). 3 During the control period, cold pressor test increased mean blood pressure by 16.0 mm Hg. Heart rate was increased by 12.5 beats/min in four patients. However, there was a reduction in heart rate (5.5 beats/min) in two other patients. During the propranolol period, cold pressor test-induced increase of mean blood pressure was not reduced but propranolol blocked the increase of heart rate. 4 Urinary catecholamine excretion rate was increased during hydrallazine administration. This excretion was not modified by propranolol.
- 研究了普萘洛尔对以下方面的影响：a) 静脉注射肼屈嗪引起的血压和心率反应；b) 冷加压试验期间这些心血管参数的变化；c) 尿儿茶酚胺排泄率。2. 静脉注射肼屈嗪显著降低平均血压15.2 mmHg，并使心率增加24.9次/分钟。普萘洛尔显著降低平均血压19.0 mmHg，心率降低14.1次/分钟。肼屈嗪加普萘洛尔导致平均血压显著降低（37.7 mmHg），但心率无显著下降（3.3次/分钟）。3. 在对照期，冷加压试验使平均血压升高16.0 mmHg。4例患者心率增加12.5次/分钟。然而另外两名患者心率下降（5.5次/分钟）。在普萘洛尔用药期间，冷加压试验引起的平均血压升高未降低，但普萘洛尔阻断了心率升高。4. 肼屈嗪给药期间尿儿茶酚胺排泄率增加。普萘洛尔未改变这种排泄。
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