Sann L, Chayvialle J A, Descos F
Eur J Pediatr. 1982 Oct;139(2):148-50. doi: 10.1007/BF00441500.
Plasma somatostatin concentration was measured by radioimmunoassay in 26 preterm neonates (mean gestational age 34 weeks). None were seriously ill and they were all fed with breast-milk 12 h after birth. In a longitudinal study the concentrations were (mean +/- SEM): 21 +/- 2 pmol/l (n = 8) at 2-8 h of age, 24 +/- 2 pmol/l (n = 11) at the age of 2 days and 25 +/- 2 pmol/l (n = 15) at the age of 8 days. These levels were significantly higher than in 30 healthy control adults: 11 +/- 1 pmol/l (P less than 0.01). Gavage with breast milk on the 2nd day induced a significant decrease from 21 +/- 4 to 15-2 pmol/l in 60 min (P less than 0.05). This data shows that the high plasma levels in neonates correspond to the high density of somatostatin in the neonatal pancreas and digestive tract. It also indicates that somatostatin is regulated by feeding in the neonate.
采用放射免疫分析法测定了26例早产儿（平均胎龄34周）的血浆生长抑素浓度。这些婴儿均无严重疾病，出生后12小时均采用母乳喂养。在一项纵向研究中，生长抑素浓度（平均值±标准误）如下：出生后2 - 8小时为21±2 pmol/l（n = 8），2日龄时为24±2 pmol/l（n = 11），8日龄时为25±2 pmol/l（n = 15）。这些水平显著高于30名健康对照成年人：11±1 pmol/l（P＜0.01）。出生后第2天经口管饲母乳60分钟后，生长抑素浓度从21±4 pmol/l显著降至15 - 2 pmol/l（P＜0.05）。该数据表明，新生儿血浆中生长抑素的高水平与新生儿胰腺和消化道中生长抑素的高密度相对应。这也表明新生儿的生长抑素受喂养调节。
