McEvoy R C, Madson K L
Biol Neonate. 1980;38(5-6):255-9. doi: 10.1159/000241373.
Insulin, glucagon and somatostatin concentration were determined in the developing pancreas between 16 days post coitum and 10 days postnatal. Plasma insulin and glucagon concentrations were also measured. Pancreatic insulin content increased rapidly during the perinatal period and peaked in concentration on day 6 postnatal. Glucagon content also increased rapidly with the largest percentage increase occurring around the time of birth. The largest increase in somatostatin also occurred postnatally. Plasma insulin and glucagon concentrations were very high during the late fetal period. the insulin concentraton fell immediately after birth and rose slowly toward adult levels during the remainder of the period examined. Plasma glucagon was high during the entire neonatal period. The degree of differentiation of the islet cells, as estimated by their content of specific hormone products, is discussed in relation to the changes in cell volume reported n the preceding paper.
在交配后16天至出生后10天的发育中的胰腺中测定了胰岛素、胰高血糖素和生长抑素的浓度。还测量了血浆胰岛素和胰高血糖素的浓度。胰腺胰岛素含量在围产期迅速增加，并在出生后第6天达到浓度峰值。胰高血糖素含量也迅速增加，最大百分比增加发生在出生前后。生长抑素的最大增加也发生在出生后。胎儿后期血浆胰岛素和胰高血糖素浓度非常高。出生后胰岛素浓度立即下降，并在检查期的其余时间缓慢上升至成人水平。整个新生儿期血浆胰高血糖素都很高。根据胰岛细胞中特定激素产物的含量估计的胰岛细胞分化程度，与前文报道的细胞体积变化相关进行了讨论。
