Shoelson S, Polonsky K, Docherty H, Jaspan J, Rubenstein A
Diabetes. 1982 May;31(5 Pt 1):474-7. doi: 10.2337/diab.31.5.474.
Somatostatin-like immunoreactivity (SLI) from dog and rat plasma eluted from Biogel P-6 columns as three distinct peaks. A large-molecular-weight peak was present in the void volume of the column, an intermediate-sized peak (SLI28) coeluted with synthetic somatostatin 28 (S-28), and a small-molecular-weight peak (SLI14) coeluted with SRIF. Material from the SLI28 peak diluted in parallel to the S-28 standard in the radioimmunoassay and behaved identically to S-28 on high pressure liquid chromatography (HPLC). Levels of SLI28 in the portal vein were consistently greater than the simultaneously measured peripheral levels (portal peripheral ratio 2.2 +/- 0.2). Venous samples drawn from multiple sites suggested that SLI28 is segregated by the duodenum and/or pancreas and the intestine. This data is consistent with the possibility that S-28 is a hormone distinct from SRIF.
从狗和大鼠血浆中洗脱得到的类生长抑素免疫反应性物质（SLI）在Biogel P - 6柱上呈现出三个不同的峰。一个大分子质量峰出现在柱的空体积中，一个中等大小的峰（SLI28）与合成生长抑素28（S - 28）共洗脱，一个小分子质量峰（SLI14）与生长抑素释放抑制因子（SRIF）共洗脱。SLI28峰的物质在放射免疫测定中与S - 28标准品平行稀释，并且在高压液相色谱（HPLC）上的行为与S - 28相同。门静脉中SLI28的水平始终高于同时测量的外周水平（门静脉与外周血水平比值为2.2±0.2）。从多个部位采集的静脉样本表明，SLI28被十二指肠和/或胰腺以及肠道分隔开来。该数据与S - 28是一种不同于SRIF的激素这一可能性相符。
