Newton R E, Casten G P, Alms D R, Benes C O, Marunycz J D
J Clin Psychiatry. 1982 Dec;43(12 Pt 2):100-2.
Animal studies and the original study comparing buspirone with diazepam and placebo indicated that sedative-hypnotic side effects and impairment in psychomotor function would be less with buspirone than with diazepam. This was borne out by the present double-blind study in which almost 700 patients received buspirone. Mean daily doses were buspirone, 20 mg; diazepam, 20 mg; and clorazepate, 24 mg. Sedation, lethargy, and depression were significantly less with buspirone than with diazepam or clorazepate and were comparable to placebo. There was no indication that other types of side effects would differ significantly from those seen with the benzodiazepines. Nervousness, headache, and dizziness were experienced more frequently with buspirone than with placebo.
动物研究以及最初一项将丁螺环酮与地西泮和安慰剂进行对比的研究表明，与地西泮相比，丁螺环酮的镇静催眠副作用以及对精神运动功能的损害更小。在目前这项有近700名患者服用丁螺环酮的双盲研究中，这一点得到了证实。平均日剂量分别为：丁螺环酮20毫克；地西泮20毫克；氯氮䓬24毫克。与地西泮或氯氮䓬相比，丁螺环酮引起的镇静、嗜睡和抑郁明显更少，且与安慰剂相当。没有迹象表明其他类型的副作用与苯二氮䓬类药物有显著差异。与安慰剂相比，服用丁螺环酮时出现紧张、头痛和头晕的频率更高。
