Saito H, Saito S, Sano T, Hosoi E, Saito H
J Clin Endocrinol Metab. 1983 Mar;56(3):567-71. doi: 10.1210/jcem-56-3-567.
The concentrations of immunoreactive somatostatin (IR-SRIF) in plasma samples taken from the umbilical artery (UA), umbilical vein (UV), and maternal antecubital vein (MV) were measured in 23 cases of normal delivery at term. High concentrations of IR-SRIF were detected in the plasma from the UA (mean +/- SD, 73.2 +/- 40.6 pg/ml), the value being about 2.5 times that in the UV (29.5 +/- 17.5 pg/ml; P less than 0.001). An arterio-venous gradient was observed in all 23 subjects. The plasma level of IR-SRIF in the MV (10.9 +/- 4.6 pg/ml) was significantly lower than those in the UA (P less than 0.001) and UV (P less than 0.001) and was almost the same as that in nonpregnant women (12.7 +/- 5.4 pg/ml). Chromatographic analysis of an extract of plasma from the UA gave only one peak of immunoreactive material, which was eluted in the same position as synthetic SRIF-14. A similar result was obtained in nonpregnant women. No correlation was found between the plasma level of IR-SRIF and that of GH, insulin, glucagon, or gastrin in the UA. The present findings suggest that the high concentration of IR-SRIF in the feto-placental circulation originates from the fetus and reflects a particular role of this peptide in the process of functional maturation of the neuroendocrine system in early human life.
对23例足月正常分娩产妇的脐动脉（UA）、脐静脉（UV）及母体肘前静脉（MV）采集的血浆样本中免疫反应性生长抑素（IR-SRIF）浓度进行了测定。UA血浆中检测到高浓度的IR-SRIF（均值±标准差，73.2±40.6 pg/ml），该值约为UV中浓度（29.5±17.5 pg/ml；P<0.001）的2.5倍。所有23名受试者均观察到动静脉梯度。MV中IR-SRIF的血浆水平（10.9±4.6 pg/ml）显著低于UA（P<0.001）和UV（P<0.001），且与未孕女性的水平（12.7±5.4 pg/ml）几乎相同。对UA血浆提取物进行色谱分析，仅得到一个免疫反应性物质峰，其洗脱位置与合成的SRIF-14相同。未孕女性也得到类似结果。UA中IR-SRIF的血浆水平与GH、胰岛素、胰高血糖素或胃泌素的血浆水平之间未发现相关性。目前的研究结果表明，胎儿-胎盘循环中IR-SRIF的高浓度源自胎儿，反映了该肽在人类生命早期神经内分泌系统功能成熟过程中的特殊作用。
