杀稻瘟菌素的抗锥虫活性。
Antitrypanosomal activity of sinefungin.
作者信息
Dube D K, Mpimbaza G, Allison A C, Lederer E, Rovis L
出版信息
Am J Trop Med Hyg. 1983 Jan;32(1):31-3. doi: 10.4269/ajtmh.1983.32.31.
PMID:6130709
Abstract
Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis--or both--in parasites.
摘要
杀稻瘟菌素是一种天然存在的抗真菌抗生素核苷，含有一个鸟氨酸残基，通过碳 - 碳键与腺苷的C - 5'相连，可治愈感染布氏布氏锥虫、刚果锥虫或活泼锥虫的小鼠；该药物对刚果锥虫的作用更为显著。杀稻瘟菌素的抗锥虫活性可能是由于抑制了寄生虫体内的转甲基反应或多胺生物合成——或者两者兼而有之。
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