西奈芬净在免疫抑制成年大鼠模型中的抗隐孢子虫治疗和预防活性
Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.
作者信息
Brasseur P, Lemeteil D, Ballet J J
机构信息
Department of Parasitology, Hôpital Charles Nicolle, Rouen, France.
出版信息
Antimicrob Agents Chemother. 1993 Apr;37(4):889-92. doi: 10.1128/AAC.37.4.889.
Abstract
An immunosuppressed rat model was used to investigate the anti-Cryptosporidium parvum activity of sinefungin. In infected animals, oral sinefungin therapy resulted in a dose-related suppression of oocyst shedding, which correlated with oocyst disappearance from ileal sections. When administered prior to or on the day of oocyst challenge, sinefungin successfully prevented infection. These data suggest that sinefungin could be considered as a candidate molecule in the treatment of human cryptosporidiosis, considered to be the most significant enteric opportunistic infection in AIDS.
摘要
使用免疫抑制大鼠模型来研究西奈芬净抗微小隐孢子虫的活性。在受感染的动物中，口服西奈芬净治疗导致卵囊排泄呈剂量相关的抑制，这与回肠切片中卵囊消失相关。在卵囊攻击前或攻击当天给药时，西奈芬净成功预防了感染。这些数据表明，西奈芬净可被视为治疗人类隐孢子虫病的候选分子，隐孢子虫病被认为是艾滋病中最重要的肠道机会性感染。
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