Lidsky T I, Labuszewski T, Levine F M
Biol Psychiatry. 1981 Dec;16(12):1189-94.
This paper concerns assessment of the full range of risks associated with prolonged use of antipsychotic medication. It is generally accepted that the most common side effects of drug therapy involve motor problems. Movement disorders arise because antipsychotics, in a substantial proportion of patients, disrupt the basal ganglia. The basal ganglia, however, are involved in much more than simply motor control. Specifically, this neural system has been implicated in sensory reactivity, attention, memory, and cognition. It follows from this that antipsychotic drugs, in addition to causing motor problems, might also disrupt complex psychological processes.
本文关注与长期使用抗精神病药物相关的全方位风险评估。人们普遍认为药物治疗最常见的副作用涉及运动问题。运动障碍的出现是因为在相当一部分患者中，抗精神病药物会扰乱基底神经节。然而，基底神经节所涉及的远不止简单的运动控制。具体而言，这个神经系统与感觉反应、注意力、记忆和认知有关。由此可见，抗精神病药物除了会导致运动问题外，还可能扰乱复杂的心理过程。
