同卵双胞胎姐妹孕期的低丙种球蛋白血症。

Hypogammaglobulinaemia during pregnancy in identical twin sisters.

作者信息

Amarin Z O, Grant K A

出版信息

Int J Gynaecol Obstet. 1982 Dec;20(6):471-3. doi: 10.1016/0020-7292(82)90008-x.

Abstract

The clinical histories and reaction to pregnancy is described in identical twin sisters with acquired hypogammaglobulinemia. Additional evidence for the genetic basis of this disorder is advanced. A possible association with myasthenia gravis is noted and the occurrence of fetal growth retardation is described. Replacement therapy should be given when the diagnosis is made, and high doses might be useful during pregnancy especially if fetal growth retardation seems to be present.

摘要

本文描述了一对患有获得性低丙种球蛋白血症的同卵双胞胎姐妹的临床病史及妊娠反应。文中还进一步提供了该疾病遗传基础的相关证据。同时指出了其与重症肌无力可能存在的关联，并描述了胎儿生长受限的情况。一旦确诊即应给予替代疗法，孕期使用高剂量疗法可能有效，尤其是在出现胎儿生长受限的情况下。