Knigge U, Dejgaard A, Wollesen F, Thuesen B, Christiansen P M
J Clin Endocrinol Metab. 1982 Jul;55(1):118-22. doi: 10.1210/jcem-55-1-118.
Histamine (HA) regulates PRL secretion in the rat by a stimulatory effect through H1-receptors and an inhibitory effect through H2-receptors. The effect of HA antagonists on basal and TRH-stimulated PRL secretion was investigated in five normal men. During saline infusion, serum PRL declined, as seen normally after sleep. HA infusion caused a significantly higher PRL secretion than that observed during the saline infusion [maximum change in PRL (delta PRL), 28 +/- 20 vs. -71 +/- 30 microIU/ml; P less than 0.05]. This effect of HA on PRL secretion was inhibited during the combined infusion of HA and the H1-antagonist mepyramine (delta PRL, 28 +/- 20 vs. -77 +/- 13 microIU/ml; P less than 0.025). The PRL-stimulating effect of HA was strongly enhanced during the combined infusion of HA and the H2-antagonist cimetidine (delta PRL, -28 +/- 20 vs. 132 +/- 57 microIU/ml; P less than 0.0125). This effect of HA and cimetidine on PRL secretion was higher than the effect of cimetidine alone (delta PRL, 132 +/- 57 vs. 17 +/- 22 microIU/ml; P less than 0.05). This shows that the H2-antagonist is not the only stimulator of PRL secretion. During the different infusions, serum PRL concentrations were in the following rank order: mepyramine less than saline less than HA less than cimetidine less than HA plus cimetidine. The same rank order was found for the PRL responses to TRH during the different infusions. These data indicate a HA stimulatory effect through H1-receptors and an inhibitory effect through H2-receptors on PRL secretion in human males.
组胺（HA）通过H1受体的刺激作用和H2受体的抑制作用来调节大鼠催乳素（PRL）的分泌。在5名正常男性中研究了HA拮抗剂对基础和促甲状腺激素释放激素（TRH）刺激的PRL分泌的影响。在输注生理盐水期间，血清PRL下降，这是睡眠后常见的情况。输注HA导致PRL分泌显著高于输注生理盐水期间观察到的水平[PRL的最大变化量（ΔPRL），28±20对-71±30 μIU/ml；P<0.05]。在HA与H1拮抗剂美吡拉敏联合输注期间，HA对PRL分泌的这种作用受到抑制（ΔPRL，28±20对-77±13 μIU/ml；P<0.025）。在HA与H2拮抗剂西咪替丁联合输注期间，HA对PRL的刺激作用强烈增强（ΔPRL，-28±20对132±57 μIU/ml；P<0.0125）。HA和西咪替丁对PRL分泌的这种作用高于单独使用西咪替丁的作用（ΔPRL，132±57对17±22 μIU/ml；P<0.05）。这表明H2拮抗剂不是PRL分泌的唯一刺激物。在不同的输注期间，血清PRL浓度按以下顺序排列：美吡拉敏<生理盐水<HA<西咪替丁<HA加西咪替丁。在不同输注期间对TRH的PRL反应也发现了相同的顺序。这些数据表明，HA通过H1受体对男性PRL分泌有刺激作用，通过H2受体有抑制作用。
