Brown M R, Fisher L A, Sawchenko P E, Swanson L W, Vale W W
Regul Pept. 1983 Jan;5(2):163-79. doi: 10.1016/0167-0115(83)90124-6.
Cysteamine given subcutaneously to rats decreases brain concentrations of somatostatin-like immunoactivity (SLI) but does not affect vasopressin-like immunoactivity as determined by radioimmunoassay and immunocytochemistry. Since somatostatin-related peptides act within the central nervous system (CNS) to increase body temperature and decrease adrenal epinephrine secretion, changes in these parameters were assessed following cysteamine administration. Cysteamine administration lowers oxygen consumption and body temperature, and elevates plasma concentrations of epinephrine, glucose, insulin and glucagon. The lowering of body temperature and elevation of plasma epinephrine is prevented by CNS administration of the CNS-selective somatostatin analog desAA1,2,4,5,12,13[D-Trp8 ))somatostatin. The CNS actions of somatostatin-related peptides are opposite to the effects of cysteamine. The observations are consistent with the possibility that brain somatostatin-related peptides are involved in regulation of body temperature and adrenal epinephrine secretion.
给大鼠皮下注射半胱胺会降低大脑中生长抑素样免疫活性（SLI）的浓度，但通过放射免疫分析和免疫细胞化学测定发现，它不会影响加压素样免疫活性。由于生长抑素相关肽在中枢神经系统（CNS）内发挥作用以升高体温并减少肾上腺肾上腺素分泌，因此在给予半胱胺后评估了这些参数的变化。给予半胱胺会降低耗氧量和体温，并升高血浆中肾上腺素、葡萄糖、胰岛素和胰高血糖素的浓度。通过中枢神经系统给予中枢选择性生长抑素类似物desAA1,2,4,5,12,13[D-Trp8 ]生长抑素可防止体温降低和血浆肾上腺素升高。生长抑素相关肽的中枢作用与半胱胺的作用相反。这些观察结果与大脑中生长抑素相关肽参与体温调节和肾上腺肾上腺素分泌调节的可能性一致。
