Kupriianova I E, Vasil'ev N V, Krasik E D
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(1):114-8.
The authors examined 176 patients with schizophrenia running an unfavourable course, treated with neuroleptics for a long time; 20 oligophrenics on prolonged neuroleptic therapy and 47 healthy subjects. The immunological status of the patients was characterized by high neutrophil damage in the presence of a complex of brain antigens, in particular those of the subcortical area (trunk and optic tuber), marked formation of hemolytic plaques, inhibition of spontaneous rosette-formation, low antithymic activity of the serum, and by a slightly elevated level of blood histamine. Administration of chlorpromazine in different concentrations led to a stimulation of plaque formation and inhibition of rosette-formation. The groups of patients with high and low responsiveness were distinguished.
作者研究了176例病程不利、长期接受抗精神病药物治疗的精神分裂症患者；20例长期接受抗精神病药物治疗的智力发育迟缓者以及47名健康受试者。患者的免疫状态特征为：在存在脑抗原复合物，特别是皮质下区域（脑干和视丘）的抗原复合物时，中性粒细胞损伤程度高；溶血空斑形成明显；自发玫瑰花结形成受到抑制；血清抗胸腺活性低；以及血液组胺水平略有升高。给予不同浓度的氯丙嗪会导致空斑形成受到刺激以及玫瑰花结形成受到抑制。区分出了高反应性和低反应性患者组。
