Domashneva I V, Minsker E I, Panteleeva G P, Tsirkin S Iu
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(8):1199-1203.
In 16 schizophrenic patients treated with aminazin changes of the serum antithymic activity (ATA) were studied in relation to the drug pharmacokinetics and peculiarities of the patients' psychic status. It was found that in a part of the patients the serum ATA level sharply fell immediately after the treatment onset; the psychopathological disturbances in these patients were reduced, and the patients developed remissions of a good quality. In another part of the patients the high serum ATA remained unchanged throughout the whole observation period. These patients were resistant to the drug therapy and had pronounced schizophrenic defects in their status.
对16例接受氯丙嗪治疗的精神分裂症患者，研究了血清抗胸腺活性（ATA）变化与药物药代动力学及患者精神状态特点的关系。发现部分患者在治疗开始后血清ATA水平立即急剧下降；这些患者的精神病理障碍减轻，病情出现了高质量的缓解。另一部分患者在整个观察期内血清ATA水平一直较高。这些患者对药物治疗耐药，且病情存在明显的精神分裂症缺陷。
