Zeledón R, Soto R, González G
Acta Trop. 1982 Dec;39(4):367-72.
Hamsters inoculated subcutaneously with Leishmania mexicana (L. m. amazonensis or L. m. mexicana) and with L. braziliensis panamensis, either simultaneously or with an interval, in different parts of the body (right front paw and nose), showed an independent course of infection for either parasite with the typical clinical and histopathological characteristics produced by these organisms. In one group of animals, metastases from the paw (L. m. amazonensis) to the nose (L. b. panamensis) was proven and the partial transformation of the granuloma from epithelioid and giant multinuclear cells (tuberculoid) to histiocytes full of parasites (lepromatous), was observed. These two specific contrasting reactions, are confined to the place of infection and influenced by the type of parasite. The histopathological picture normally observed in hamsters as a reaction to L. mexicana s.1., occurs only occasionally in humans. It is suggested, on the basis of this animal model, that DCL in the New World is only produced by parasites of the "mexicana" complex and that both parasite characteristics and host immune status are responsible for this phenomenon.
仓鼠分别在身体不同部位（右前爪和鼻子）皮下接种墨西哥利什曼原虫（亚马逊利什曼原虫或墨西哥利什曼原虫）和巴拿马利什曼原虫，无论是同时接种还是间隔接种，两种寄生虫的感染过程相互独立，呈现出由这些生物体产生的典型临床和组织病理学特征。在一组动物中，证实了从爪子（亚马逊利什曼原虫）到鼻子（巴拿马利什曼原虫）的转移，并观察到肉芽肿从上皮样和巨大多核细胞（结核样）部分转变为充满寄生虫的组织细胞（瘤型）。这两种特定的对比反应局限于感染部位，并受寄生虫类型影响。仓鼠对墨西哥利什曼原虫复合种产生反应时通常观察到的组织病理学表现，在人类中仅偶尔出现。基于这个动物模型，有人提出，新大陆的弥漫性皮肤利什曼病仅由“墨西哥利什曼原虫”复合种的寄生虫引起，并且寄生虫特征和宿主免疫状态都是导致这种现象的原因。
