Chinchilla M, Guerrero O M, Portilla E
Rev Biol Trop. 1980 Jul;28(1):109-19.
Groups of "immunized" and "non-immunized" hamsters were inoculated weekly with 2, 10 or 20 mg of cortisone acetate per 100 gr of body weight and infected with Leishmania mexicana or L. braziliensis. Doses of 10 and 20 mg of cortisone were excessive, since the animals died with bacterial infections before they developed leishmaniasis. Inflammation and necrosis were more evident in animals inoculated with cortisone and L. mexicana. Furthermore, this strain caused lesions in lymphatic ganglia of immunosuppressed animals, but was not observed in those inoculated with L. braziliensis. There was no difference between the pathological findings in nonimmune and immune hamsters. These results could indicate that passive immunization with dead antigen is not effective.
将“免疫”和“未免疫”的仓鼠分组，每周按每100克体重接种2、10或20毫克醋酸可的松，并感染墨西哥利什曼原虫或巴西利什曼原虫。10毫克和20毫克醋酸可的松的剂量过高，因为动物在患利什曼病之前就死于细菌感染。接种了可的松和墨西哥利什曼原虫的动物炎症和坏死更为明显。此外，该菌株在免疫抑制动物的淋巴节中引起病变，但在接种巴西利什曼原虫的动物中未观察到。未免疫和免疫仓鼠的病理结果没有差异。这些结果可能表明用死抗原进行被动免疫无效。
