无症状淋病女性中针对淋球菌菌毛的抗体。酶联免疫吸附测定法（ELISA）对性病门诊就诊女性进行检测的诊断价值。
Antibodies to gonococcal pili in women with asymptomatic gonorrhoea. Diagnostic value of the ELISA for testing women attending an STD clinic.
作者信息
Oranje A P, Iserief C O, de Roo A, Stolz E, Michel M F
出版信息
Br J Vener Dis. 1983 Apr;59(2):85-8. doi: 10.1136/sti.59.2.85.
The diagnostic efficacy of an enzyme-linked immunosorbent assay (ELISA) using gonococcal pili 6650 as antigen was studied in asymptomatic women attending an STD clinic. Of the 182 women studied, gonorrhoea was diagnosed in 29%. The value of the ELISA was calculated on the basis of four arbitrary cut-off points in the test. The best predictive values for a positive result (PV(+)) were obtained at an absorbance value of A greater than or equal to 1.15 and A greater than or equal to 1.30 and that for a negative result at A greater than or equal to 0.85. When patients with a history of gonorrhoea were excluded, the PV(+) rose only at A greater than or equal to 1.15 (not at A greater than or equal to 1.30) and the PV(-) rose slightly. To be of use in the diagnosis of gonorrhoea in asymptomatic patients the ELISA should be used as follows: the result is positive at A greater than or equal to 1.15 and negative at A less than 0.85, the PV(+) then being 0.52 and the PV(-) 0.85. Whenever sera give a result between A = 0.85 and A = 1.15, the test should be repeated.
在一家性传播疾病诊所就诊的无症状女性中，研究了以淋球菌菌毛6650作为抗原的酶联免疫吸附测定（ELISA）的诊断效力。在182名接受研究的女性中，29%被诊断为淋病。ELISA的值是根据该检测中的四个任意临界值计算得出的。阳性结果的最佳预测值（PV(+)）在吸光度值A大于或等于1.15以及A大于或等于1.30时获得，阴性结果的最佳预测值在A大于或等于0.85时获得。当排除有淋病病史的患者后，PV(+)仅在A大于或等于1.15时上升（在A大于或等于1.30时未上升），而PV(-)略有上升。为用于无症状患者淋病的诊断，ELISA应按如下方式使用：在A大于或等于1.15时结果为阳性，在A小于0.85时结果为阴性，此时PV(+)为0.52，PV(-)为0.85。每当血清给出的结果在A = 0.85和A = 1.15之间时，应重复该检测。
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