每日两次雷尼替丁与标准西咪替丁治疗十二指肠溃疡的比较。
Comparison of twice-daily ranitidine with standard cimetidine treatment of duodenal ulcer.
作者信息
Walt R P, Trotman I F, Frost R, Golding P L, Shepherd T H, Rawlings J, Hunt R H, Colin-Jones D, Milton-Thompson G J, Misiewicz J J
出版信息
Gut. 1981 Apr;22(4):319-22. doi: 10.1136/gut.22.4.319.
Abstract
One hundred and three outpatients with endoscopically diagnosed duodenal ulcer were randomly allocated to treatment with either cimetidine 200 mg tds and 400 mg nocte, or ranitidine 150 mg bd for four weeks. The endoscopists were not aware of the treatment and took no part in the clinical management. On completion of treatment ulcers had healed in 43 of 51 (84%) patients given cimetidine and in 40 of 52 (77%) patients given ranitidine. There were no serious unwanted effects in either treatment group. The results show no significant difference between healing rates after four weeks of standard cimetidine therapy or ranitidine 150 mg bd.
摘要
103例经内镜诊断为十二指肠溃疡的门诊患者被随机分为两组，一组接受西咪替丁治疗，剂量为每日3次，每次200mg，夜间加服400mg；另一组接受雷尼替丁治疗，剂量为每日2次，每次150mg，疗程均为4周。内镜检查医生不知道患者的治疗情况，也未参与临床管理。治疗结束时，接受西咪替丁治疗的51例患者中有43例（84%）溃疡愈合，接受雷尼替丁治疗的52例患者中有40例（77%）溃疡愈合。两个治疗组均未出现严重不良反应。结果显示，标准剂量西咪替丁治疗4周与雷尼替丁每日2次、每次150mg治疗4周后的愈合率无显著差异。
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