Calam J, Unwin R, Peart W S
Lancet. 1983 Apr 2;1(8327):737-8. doi: 10.1016/s0140-6736(83)92028-7.
Five normal adults defaecated within 2 1/2 hours of receiving neurotensin 13.5 pmol kg-1 min-1 for 30 min, whereas none did so after control infusions, in a double-blind study. Neurotensin caused borborygmi and production of stools which resembled the normal contents of the proximal and distal colon in terms of consistency and electrolyte content. This evidence suggests that neurotensin had a major effect on propulsive colonic motility. Blood neurotensin concentrations during infusion were about three times higher than normal postprandial concentrations, but plasma neurotensin is raised in some diseases associated with diarrhoea.
在一项双盲研究中，五名正常成年人在以13.5皮摩尔/千克/分钟的剂量接受30分钟的神经降压素输注后，在2个半小时内排便，而在对照输注后无人排便。神经降压素引起肠鸣音并产生粪便，这些粪便在稠度和电解质含量方面类似于近端和远端结肠的正常内容物。这一证据表明，神经降压素对结肠推进性运动有重大影响。输注期间血液中的神经降压素浓度比正常餐后浓度高约三倍，但在一些与腹泻相关的疾病中血浆神经降压素会升高。
