Hall G A, Parsons K R, Bridger J C, Ghatei M A, Ying Y C, Bloom S R
Res Vet Sci. 1985 Jan;38(1):99-103. doi: 10.1016/S0034-5288(18)31855-1.
Five gnotobiotic calves were each infected with five viruses. Each calf was inoculated with coronavirus at seven days old, followed by astrovirus, Newbury agent, parainfluenzavirus type 3 and rotavirus at intervals of two weeks. Three of the viruses were enteropathogenic (bovine coronavirus, bovine calici-like virus and bovine rotavirus) and two were not (bovine astrovirus and parainfluenzavirus type 3). Plasma levels of the peptide hormones enteroglucagon and neurotensin and faecal output were measured daily and xylose absorption was studied before and after each infection. A close correlation was found between a rise in plasma enteroglucagon and neurotensin and infection with enteropathogenic viruses. The three enteropathogenic viruses caused increased daily faecal output, and elevated plasma levels of enteroglucagon and neurotensin, while the non-enteropathogens did not. The calici-like virus and rotavirus but not the coronavirus caused xylose malabsorption.
五只无菌小牛每只感染五种病毒。每只小牛在7日龄时接种冠状病毒，随后每隔两周依次接种星状病毒、纽伯里病毒、3型副流感病毒和轮状病毒。其中三种病毒是肠道致病性的（牛冠状病毒、牛杯状病毒样病毒和牛轮状病毒），两种不是（牛星状病毒和3型副流感病毒）。每天测量肽类激素肠高血糖素和神经降压素的血浆水平以及粪便排出量，并在每次感染前后研究木糖吸收情况。发现血浆肠高血糖素和神经降压素的升高与肠道致病性病毒感染之间存在密切相关性。三种肠道致病性病毒导致每日粪便排出量增加，以及血浆肠高血糖素和神经降压素水平升高，而非肠道致病性病毒则没有这种情况。杯状病毒样病毒和轮状病毒而非冠状病毒导致木糖吸收不良。
