Mahmoud A A, Siongok T A, Ouma J, Houser H B, Warren K S
Lancet. 1983 Apr 16;1(8329):849-51. doi: 10.1016/s0140-6736(83)91388-0.
The effect of targeted mass treatment, a new strategy for cost-effective control of schistosomiasis mansoni based on administering single-dose chemotherapeutic agents to individuals with disease manifestations (hepatosplenomegaly) or heavy infections, was evaluated in an endemic area in Kenya. Two years after treatment of subjects with hepatosplenomegaly, the mean liver midsternal-line measurement decreased from 6 x 5 +/- 0 x 6 to 2 x 9 +/- 0 x 5 cm and the mean faecal egg count dropped significantly from its pretreatment level of 1090 +/- 290/g to 88 +/- 31/g. Targeted chemotherapy was then administered to a group of 122 subjects with faecal egg counts greater than or equal to 400/g. A similar maintained decrease in egg counts after chemotherapy was demonstrated in this group; mean egg count after one year was 115 +/- 17/g compared with 1250 +/- 232/g before treatment. The yearly rate of acquisition of heavy infection in this community was low (7%) and did not differ significantly in the uninfected, lightly infected, or heavily infected (and treated) groups.
基于向有疾病表现（肝脾肿大）或重度感染的个体施用单剂量化疗药物的曼氏血吸虫病经济有效控制新策略——靶向群体治疗，在肯尼亚的一个流行地区进行了评估。对患有肝脾肿大的受试者进行治疗两年后，肝脏中线胸骨测量平均值从6×5±0×6降至2×9±0×5厘米，粪便虫卵计数从治疗前的1090±290/克显著降至88±31/克。然后对一组粪便虫卵计数大于或等于400/克的122名受试者进行了靶向化疗。该组化疗后虫卵计数也出现了类似的持续下降；一年后的平均虫卵计数为115±17/克，而治疗前为1250±232/克。该社区每年重度感染的发生率较低（7%），在未感染、轻度感染或重度感染（且接受治疗）组中无显著差异。
