Polderman A M, Manshande J P
Lancet. 1981 Jan 3;1(8210):27-8. doi: 10.1016/s0140-6736(81)90127-6.
An attempt was made to control schistosomiasis mansoni with mass treatment of all subjects excreting more than 100 eggs/g of faeces. No other means of control to reduce transmission were used. A very low dosage of hycanthone (0.75 mg/kg) appeared insufficient to achieve a satisfactory reduction of the worm load. A higher dosage (1.5 mg/kg) resulted in a significant reduction of the egg output. However, reappearance of eggs, probably indicating reinfection, was very rapid. One year after treatment the egg counts were at about two-thirds of the original level again.
尝试通过对所有每克粪便虫卵排出量超过100个的受试者进行群体治疗来控制曼氏血吸虫病。未使用其他控制传播的方法。极低剂量的海恩酮（0.75毫克/千克）似乎不足以实现对虫负荷的满意降低。较高剂量（1.5毫克/千克）导致虫卵排出量显著减少。然而，虫卵再次出现，可能表明再次感染，速度非常快。治疗一年后，虫卵计数又回到了原来水平的大约三分之二。
