Harries A D, Jones L A, Danis V, Fifield R, Heatley R V, Newcombe R G, Rhodes J
Lancet. 1983 Apr 23;1(8330):887-90. doi: 10.1016/s0140-6736(83)91325-9.
28 malnourished patients with Crohn's disease completed a controlled cross-over study to examine the effect of a low-residue liquid supplement on nutrition and disease activity. Patients spent two months on an ordinary diet (control period) and for two months took the nutritional supplement in addition (treatment period): the order of treatment and control periods was randomised. All anthropometric measurements, serum proteins, creatinine height index, and circulating T lymphocyte numbers increased significantly in the treatment period, while serum orosomucoid levels dropped significantly, suggesting that disease activity was reduced. The benefits were apparently due to the higher calorie intake with the enteral supplement. The results show that enteral supplementation can be managed successfully at home and may produce improvements in nutrition and disease activity.
28名患有克罗恩病的营养不良患者完成了一项对照交叉研究，以检验低残渣液体补充剂对营养状况和疾病活动的影响。患者先进行两个月的普通饮食（对照期），然后再进行两个月的普通饮食并额外服用营养补充剂（治疗期）：治疗期和对照期的顺序是随机的。在治疗期，所有人体测量指标、血清蛋白、肌酐身高指数和循环T淋巴细胞数量均显著增加，而血清类粘蛋白水平显著下降，这表明疾病活动度降低。这些益处显然归因于肠内补充剂带来的更高热量摄入。结果表明，肠内补充剂可在家中成功管理，并且可能改善营养状况和疾病活动度。
