Okuma Y, Osumi Y, Ishikawa T, Nagata M
Life Sci. 1983 Mar 21;32(12):1363-70. doi: 10.1016/0024-3205(83)90812-3.
Possible roles of noradrenaline (NA) and acetylcholine (ACh) within the lateral hypothalamic area (LHA) in regulation of gastric acid secretion were examined in urethane anesthetized rats. When NA 30 nmoles was given into the LHA, the gastric acid output decreased and this inhibitory effect of NA was potentiated in rats pretreated with reserpine (2 mg/kg, i.p., 20 hr). Even in a dose of 3 nmoles which was without effect in non-treated control animals, there was a remarkable decrease in acid output. In these reserpinized animals, ACh in a dose of 30 nmoles induced a remarkable increase in acid output, while in the controls this ACh-induced increase was observed only with a 10 times higher dose. In the rats not given reserpine, the cholinergic muscarinic agonist bethanechol (10 nmoles) increased the gastric acid output while nicotine (30 nmoles) was without effect. Therefore, in rats, the central noradrenergic inhibitory mechanisms related to regulation of gastric function may be present at the level of LHA as well as at the ala cinerea (area of the dorsal motor nucleus of vagi and the nucleus tractus solitarius). In addition, in the LHA, a cholinergic muscarinic mechanism which elevates gastric acid secretion may be antagonized by a noradrenergic inhibitory mechanism.
在乌拉坦麻醉的大鼠中，研究了去甲肾上腺素（NA）和乙酰胆碱（ACh）在下丘脑外侧区（LHA）对胃酸分泌调节中的可能作用。当向LHA注射30纳摩尔NA时，胃酸分泌量减少，在用利血平（2毫克/千克，腹腔注射，20小时）预处理的大鼠中，NA的这种抑制作用增强。即使是3纳摩尔的剂量，在未处理的对照动物中无效，但胃酸分泌量也有显著下降。在这些利血平化的动物中，30纳摩尔剂量的ACh可使胃酸分泌量显著增加，而在对照动物中，只有10倍高的剂量才能观察到ACh诱导的增加。在未给予利血平的大鼠中，胆碱能毒蕈碱激动剂氨甲酰甲胆碱（10纳摩尔）可增加胃酸分泌量，而尼古丁（30纳摩尔）则无作用。因此，在大鼠中，与胃功能调节相关的中枢去甲肾上腺素能抑制机制可能存在于LHA水平以及灰翼（迷走神经背运动核和孤束核区域）。此外，在LHA中，一种增加胃酸分泌的胆碱能毒蕈碱机制可能被去甲肾上腺素能抑制机制所拮抗。
