Osumi Y, Ishikawa T, Okuma Y, Nagasaka Y, Fujiwara M
Eur J Pharmacol. 1981 Oct 15;75(1):27-35. doi: 10.1016/0014-2999(81)90341-1.
To investigate the possible role of central noradrenergic neurons in the regulation of gastric functions, electrical stimulation of the locus coeruleus [LC] and microinjection of noradrenaline [NA] into the ala cinerea (area of the dorsal motor nucleus of the vagi [NDV] and the nucleus tractus solitarius [NTS]) were given to urethane-anesthetized rats. Unilateral electrical stimulation of the LC decreased both the basal levels and the lateral hypothalamic area [LHA]-induced increases in gastric acid output and mucosal blood flow. Microinjection of NA 0.1 and 0.5 micrograms/animal into the ala cinerea also decreased the basal levels of these gastric parameters. From these results, combined with neuroanatomical data from the literature, it is concluded that central noradrenergic inhibitory mechanisms originating from the LC seem to be involved in the regulation of gastric functions, probably at the level of the brain-stem ala cinerea.
为研究中枢去甲肾上腺素能神经元在胃功能调节中的可能作用，对氨基甲酸乙酯麻醉的大鼠进行蓝斑[LC]电刺激以及向灰翼（迷走神经背运动核[NDV]和孤束核[NTS]所在区域）微量注射去甲肾上腺素[NA]。单侧电刺激LC可降低基础水平以及下丘脑外侧区[LHA]诱导的胃酸分泌和黏膜血流量增加。向灰翼每只动物微量注射0.1和0.5微克NA也可降低这些胃参数的基础水平。结合文献中的神经解剖学数据，从这些结果可以得出结论，源自LC的中枢去甲肾上腺素能抑制机制似乎参与胃功能的调节，可能是在脑干灰翼水平。
