Bond A, Lader M
Pharmacol Biochem Behav. 1983 Feb;18(2):295-8. doi: 10.1016/0091-3057(83)90381-7.
A retrospective analysis of five studies using benzodiazepines and one using a benzodiazepine-like drug, zopiclone, and involving 61 subjects in toto was carried out. All used a placebo control and all acute studies incorporated pre-treatment values as well. Eight variables which have previously been shown to be sensitive to benzodiazepine action and which covered a range of physiological, psychological and subjective measures were chosen. Within-subject correlations between drug minus placebo values for these variables were computed to examine relationships between the measures while the subjects were taking benzodiazepines. It was found that closely related measures within system were significantly correlated but other correlations were sparse. However under limited conditions, i.e., several doses of one drug in the same subjects as in the zopiclone study, a consistent pattern of effects was shown across measures, resulting in half of the possible correlations showing statistical significance. A similar pattern was shown in patients after 2-4 weeks treatment with benzodiazepines.
对五项使用苯二氮䓬类药物的研究和一项使用类似苯二氮䓬类药物佐匹克隆的研究进行了回顾性分析，总计涉及61名受试者。所有研究均采用安慰剂对照，且所有急性研究均纳入了治疗前的值。选择了八个先前已证明对苯二氮䓬类药物作用敏感的变量，这些变量涵盖了一系列生理、心理和主观测量指标。计算这些变量的药物减去安慰剂值之间的受试者内相关性，以检查受试者服用苯二氮䓬类药物时各测量指标之间的关系。结果发现，系统内密切相关的测量指标显著相关，但其他相关性较少。然而，在有限的条件下，即在与佐匹克隆研究相同的受试者中使用一种药物的几个剂量时，各测量指标显示出一致的效应模式，导致一半的可能相关性具有统计学意义。在使用苯二氮䓬类药物治疗2至4周后的患者中也显示出类似的模式。
