Golodets R G, Govoroin N V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(2):249-53.
Seventy-two patients with acute alcoholic delirium were examined cliniconeurophysiologically. The Athena scale, neurovegetative indices as well as those of adrenaline, noradrenaline, dopamine, and DOPA excretion were used for delirium gravity estimation. Proceeding from these data an attempt was made to use the beta-blocking agent obsidan for combined delirium treatment. The data obtained allow using the pathogenetic drugs for differentiated search of delirium treatment. Application of obsidan, an agent blocking hyperactivity of central adrenergic mechanisms in abortive and typical delirium promoted the removal of affective disorders, normalized hemodynamics and prevented early exhaustion of adrenergic mechanisms. Thus, obsidan produces favorable therapeutic effects when used in a complex of measures for alcoholic delirium treatment.
对72例急性酒精性谵妄患者进行了临床神经生理学检查。使用雅典娜量表、神经植物性指标以及肾上腺素、去甲肾上腺素、多巴胺和多巴排泄指标来评估谵妄的严重程度。基于这些数据，尝试使用β受体阻滞剂奥布西丹联合治疗谵妄。所获得的数据有助于使用病因药物进行谵妄治疗的差异化探索。在先兆性和典型谵妄中，应用能阻断中枢肾上腺素能机制亢进的奥布西丹，可促进情感障碍的消除，使血流动力学正常化，并防止肾上腺素能机制过早耗竭。因此，在酒精性谵妄的综合治疗措施中使用奥布西丹可产生良好的治疗效果。
