Mänttäri M, Eisalo A
Acta Med Scand Suppl. 1982;668:114-7. doi: 10.1111/j.0954-6820.1982.tb08532.x.
In a double-blind crossover study the antihypertensive effect of acebutol (I.S.A. and M.S.A.) 400 to 800 mg daily was compared with that of metoprolol (non-I.S.A. and non-M.S.A.) 200 to 400 mg daily. Blood pressure and heart-rate were measured sitting, lying and post-exercise. Twenty-eight patients entered the trial, but 4 were withdrawn for reasons not connected with active treatment. There was no significant difference between the drugs in their ability to reduce the systolic and diastolic blood pressure sitting, lying or post-exercise or reduce the heart-rate post-exercise. Metoprolol reduced the heart-rate sitting and lying to a significantly greater degree (p less than 0.05) than acebutolol. While the antihypertensive effect seems to be entirely dependent on beta-blockade, the I.S.A. may still have some value for patients with a low heart rate at rest.
在一项双盲交叉研究中，比较了每日400至800毫克醋丁洛尔（具有内在拟交感活性和膜稳定活性）与每日200至400毫克美托洛尔（无内在拟交感活性和膜稳定活性）的降压效果。测量了患者坐着、躺着以及运动后的血压和心率。28名患者进入试验，但4名因与积极治疗无关的原因退出。两种药物在降低坐着、躺着或运动后的收缩压和舒张压，或降低运动后心率的能力方面没有显著差异。美托洛尔在降低坐着和躺着时的心率方面比醋丁洛尔显著更有效（p小于0.05）。虽然降压作用似乎完全依赖于β受体阻滞，但内在拟交感活性对于静息心率较低的患者可能仍有一定价值。
