Mader Reuven, Segol Ori, Adawi Muhammed, Trougoboff Philippe, Nussinson Elchanan
Rheumatic Diseases Unit, Ha'Emek Medical Center, Afula 18101, Israel.
Rheumatol Int. 2005 Aug;25(6):401-5. doi: 10.1007/s00296-004-0470-0. Epub 2004 Apr 20.
The aim of this study was to describe arthritis or vasculitis as initial manifestations of Crohn's disease (CD).
We describe three cases in which the rheumatological manifestations preceded the bowel disease and one with rheumatological manifestation and asymptomatic gut inflammation. The information on clinical manifestations, laboratory examination results, imaging procedures, and histological data were gathered from the patients' medical charts. A MEDLINE search for the associations of extraintestinal manifestations of inflammatory bowel disease was performed.
Arthritis or vasculitis preceded the bowel disease by 3 to 15 months. In one case, the bowel disease remained asymptomatic throughout the follow-up period.
Rheumatological presentations of CD such as arthritis and vasculitis are uncommon. The diagnosis of CD without evident bowel symptoms might offer explanations and treatment options for puzzling symptoms and signs. Recognition, early diagnosis, and treatment of the underlying gut disease might prove useful for both the bowel disease and the rheumatological manifestations.
本研究旨在描述关节炎或血管炎作为克罗恩病（CD）的初始表现。
我们描述了3例风湿性表现先于肠道疾病出现的病例，以及1例有风湿性表现但肠道无症状性炎症的病例。从患者病历中收集了关于临床表现、实验室检查结果、影像学检查和组织学数据的信息。对炎性肠病肠外表现的相关性进行了医学文献数据库（MEDLINE）检索。
关节炎或血管炎先于肠道疾病出现3至15个月。在1例病例中，整个随访期间肠道疾病均无症状。
CD的风湿性表现如关节炎和血管炎并不常见。无明显肠道症状的CD诊断可能为令人困惑的症状和体征提供解释及治疗选择。识别、早期诊断和治疗潜在的肠道疾病可能对肠道疾病和风湿性表现均有益。
